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Reports and Studies

Improving Risk Assessment Approaches For Chemicals With Both Endogenous And Exogenous Exposures

This commentary provides a systematic approach for risk assessors to consider and address exogenous exposures to endogenous or background chemicals “up front” in the problem formulation step in order to make it an integral part of risk assessment, and to effectively engage risk managers and peers early in the process to allow regulatory options to inform the focus and scope of such risk assessments.

Reports and Studies

Dose-Dependence Of Chemical Carcinogenicity: Biological Mechanisms For Thresholds And Implications For Risk Assessment

The review highlights some of the key discoveries and technological advances that have influenced scientific understanding of chemical carcinogenesis over the last fifty years and provides case studies to demonstrate the utility of these modern technologies in providing a biologically robust evaluation of chemical dose-response for cancer risk assessment.