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Reports and Studies

Dosimetry of N 6-Formyllysine Adducts Following [13C2H2]-Formaldehyde Exposures in Rats

With formaldehyde as the major source of endogenous N⁶-formyllysine protein adducts, we quantified endogenous and exogenous N⁶-formyllysine in the nasal epithelium of rats exposed by inhalation to 0.7, 2, 5.8, and 9.1 ppm [¹³C²H₂]-formaldehyde using liquid chromatography-coupled tandem mass spectrometry.

Health Effects of Diisocyanates Guidance for Medical Personnel

This guidance document is designed specifically for medical personnel to provide current information about the potential health effects from diisocyanate eposure, and to provide guidance to assist with medical diagnosis and management. The discussion focuses on two widely used diisocyanate-based products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI). (AX-150, 2013)

Reports and Studies

Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates

Formaldehyde is an air pollutant present in both indoor and outdoor atmospheres. Because of its ubiquitous nature, it is imperative to understand the mechanisms underlying formaldehyde- induced toxicity and carcinogenicity. MicroRNAs (miRNAs) can influence disease caused by environmental exposures, yet miRNAs are understudied in relation to formaldehyde. Our previous investigation demonstrated that formaldehyde exposure in human lung cells caused disruptions in miRNA expression profiles in vitro.

TDI Transportation Guidelines Spanish

TDI Transportation Guidelines: This 54-page technical guideline provides a summary of regulatory requirements affecting the transport and distribution of TDI, and relevant industry safety guidelines.