Current Projects - American Chemistry Council

Abstracts for Current Projects

Project abstracts are a primary source of information regarding the status and progress for LRI’s currently funded projects. These abstracts are provided each year by the principal investigators as a key part of their research agreement with LRI. Links to abstracts for each of these projects are located at the end of the project titles in the list below. See the ACC Research Catalog to access publications from current and past LRI research projects.

Current LRI Research Project Portfolio: 14

Accelerating Exposure Science for Product Stewardship, Sustainability and Regulatory Decision-Making

Project Title: Expanding and Improving the EAS-E Suite Platform for Exposure Modeling
Principal Investigator: Jon Arnot, Ph.D.
Research Institution: ARC Arnot Research & Consulting Inc.

Project Title: Exposure Research Using Robotics to Measure Concentrations / Verify Exposure Model Predictions
Principal Investigator: Albania Grosso
Research Institution: Lower Olefins and Aromatics REACH Consortium (A.G.) and Stantec (H.L.)

Advancing New Approach Methods (NAMs) for Application in Risk Assessment through Development of Scientific Confidence

Project Title: Using the New ICCVAM NAM Validation Guidance to Evaluate the Threshold of Toxicological Concern as a Computational NAM
Principal Investigator: Susan Borghoff, Ph.D.; Chadwick M. Thompson, Ph.D, M.B.A
Research Institution: ToxStrategies, Inc.

Project Title: Development of a Tiered Approach for the Application of In Vitro to In Vivo Extrapolation (IVIVE) for Developmental Toxicity in Support of New Approach method (NAM)- Based Chemical Safety Assessments
Principal Investigator: Harvey Clewell, Ph.D.
Research Institution: Ramboll

Project Title: Exploring Tissue Chips for Toxicity Testing: Testing Consortium at Texas A&M University (TEX-VAL)
Principal Investigators: Ivan Rusyn, Ph.D.,; Courtney Sakolish, Ph.D.,; Clifford Stephan Ph.D.
Research Institution: Texas A&M University

Project Title: Advancing Respiratory Tract Cell Culture NAM Models for Risk-Based Decision-Making
Principal Investigators: Joanne Wallace, Ph.D.; Seyoum Ayehunie, Ph.D.
Research Institution: Charles River Laboratories Edinburgh and MatTek

Project Title: Omics for Assessing Signatures for Integrated Safety (OASIS) Consortium
Consortium Manager: Chrissy Crute, Ph.D.
Research Institution: Health and Environmental Sciences Institute (HESI)

Project Title: Developing In Vitro Metabolic Clearance Data to Support Development of the Internal Threshold of Toxicological Concern (iTTC)
Principal Investigator: Sherry Black
Research Institution: RTI

ACC LRI Focus Area: Strengthening Public Health Science Approaches for Evaluating Co-exposures and Cumulative Impacts in Communities

Project Title: Investigating Dose Addition and Response Addition for Risk Assessment of Mixtures
Principal Investigator: Paul Price, Ph.D.
Research Institution: Risk Sciences International

Project Title: A Comprehensive Review and Appraisal of Frameworks, Methods, Metrics, and Data Used in Assessments of Communities with Environmental Justice Concerns
Principal Investigators: William Rish, Ph.D; Ann Verwiel
Research Institution: ToxStrategies, Inc.

Project Title: Evaluating Morphological, Behavioral & Transcriptomic Responses in the Zebrafish Developmental Toxicity Assay to Chemical Mixtures Commonly Associated with Environmental and Human Biomonitoring Studies
Principle Investigator: Robyn Tanguay, Ph.D.
Research Institution: Oregon State University

Project Title: Creating and Sustaining Successful Public-Private Partnerships (PPPs) for Environmental Monitoring Programs: Principles and Elements
Principal Investigator: Judy LaKind, Ph.D.
Research Institution: LaKind Associates, LLC

Project Title: Exploring Artificial Intelligence Technologies to Develop a “Causal Research Assistant”
Principal Investigator: Tony Cox, Ph.D.
Research Institution: Cox Associates

Project Title: Adapting an Interactive Infographic to Communicate Disease Risk Factors in Environmentally Disadvantaged Communities
Principal Investigators: Ann Verwiel; Daniele Wikoff, Ph.D.; William R. Rish, Ph.D
Research Institution: ToxStrategies, Inc.