Current Projects

Abstracts for Current Projects

Project abstracts are a primary source of information regarding the status and progress for LRI’s currently funded projects. These abstracts are provided each year by the principal investigators as a key part of their research agreement with LRI. Links to abstracts for each of these projects are located at the end of the project titles in the list below. See the ACC Research Catalog to access publications from current and past LRI research projects.

Current LRI Research Project Portfolio: 10

Advance Understanding of Consumer Exposures: Predictive Models for Generating Exposure Estimates

Project Title: Comparing Estimates of Chemical Use Between Two Separate Databases: the Euromonitor U.S. Dataset and the EPA’s CPDat (pdf)
Principal Investigator: Gouin, Todd
Research Institution: TG Environmental Research

Project Title: EAS-E Suite Phase 1 Proof of Concept: Integrating different dermal exposure models with tiered PBPK models (pdf)
Principal Investigator: Arnot, Jon
Research Institution: ARC Arnot Research & Consulting Inc.

Project Title: Improving Exposure Models and Integrating Exposure and Risk Information for High-Throughput Chemical Screening (Prioritization) and Higher Tiered Assessments (pdf)
Principal Investigator: Arnot, Jon
Research Institution: ARC Arnot Research & Consulting Inc.

Integrate Hazard and Exposure to Assess Risks from Chemicals: New Tools for Linking the Data

Project Title: Population Life-course Exposure to Health Effects Model (PLETHEM) - Continued Platform Development (pdf)
Principal Investigator: Fitzpatrick, Jeremy
Research Institution: ScitoVation

Improve Chemical Safety Testing Technologies: Design Fit-for-Purpose Assays and Advance Data Interpretation

Project Title: Development of Fit-For-Purpose Multifunctional Liver Co-Culture System (pdf)
Principal Investigator: McMullen, Patrick
Research Institution: ScitoVation

Project Title: Development of a fit-for-purpose in vitro model of lung toxicity (pdf)
Principal Investigator: Slattery, Scott
Research Institution: ScitoVation

Project Title: Predicting Mode of Action from Toxicogenonomic Data (pdf)
Principal Investigator: McMullen, Patrick
Research Institution: ScitoVation

Address Topical Challenges Faced by the Chemical Industry: Novel Techniques and Tools

Project Title: Developing In Vitro Metabolic Clearance Data to Support Development of the Internal Threshold of Toxicological Concern (iTTC) (pdf)
Principal Investigator: Black, Sherry
Research Institution: RTI

Project Title: Evaluation of USEPA’s Generalized Read-Across (GenRA) and Selected Example Case Studies to Identify Challenges and Recommendations to Consider for GenRA Improvements (pdf)
Principal Investigator: Borghoff, Susan
Research Institution: ToxStrategies

Project Title: Survey and Development of a Peer Review Process for Exposure Models (pdf)
Principal Investigator: Hays, Sean
Research Institution: SciPinion