Current Projects

Abstracts for Current Projects

Project abstracts are a primary source of information regarding the status and progress for LRI’s currently funded projects. These abstracts are provided each year by the principal investigators as a key part of their research agreement with LRI. Links to abstracts for each of these projects are located at the end of the project titles in the list below. See the ACC Research Catalog to access publications from current and past LRI research projects.

Current LRI Research Project Portfolio: 11

Advance Understanding of Consumer Exposures: Predictive Models for Generating Exposure Estimates

Project Title: Comparing Estimates of Chemical Use Between Two Separate Databases: the Euromonitor U.S. Dataset and the EPA’s CPDat
Principal Investigator: Gouin, Todd
Research Institution: TG Environmental Research

Project Title: EAS-E Suite Phase 1 Proof of Concept: Integrating different dermal exposure models with tiered PBPK models (pdf)
Principal Investigator: Arnot, Jon
Research Institution: ARC Arnot Research & Consulting Inc.

Project Title: Expanding and Improving the EAS-E Suite Platform for Exposure Modeling
Principal Investigator: Arnot, Jon
Research Institution: ARC Arnot Research & Consulting Inc.

Integrate Hazard and Exposure to Assess Risks from Chemicals: New Tools for Linking the Data

Project Title: Population Life-course Exposure to Health Effects Model (PLETHEM) - Continued Platform Development
Principal Investigator: Fitzpatrick, Jeremy
Research Institution: ScitoVation

Project Title: Development of a Tiered Approach for the Application of In Vitro to In Vivo Extrapolation (IVIVE) for Developmental Toxicity in Support of New Approach Method (NAM) - Based Chemical Safety Assessments
Principal Investigator: Clewell, Harvey
Research Institution: Ramboll

Improve Chemical Safety Testing Technologies: Design Fit-for-Purpose Assays and Advance Data Interpretation

Project Title: Development of Fit-For-Purpose Multifunctional Liver Co-Culture System
Principal Investigator: Scaglione, Jamie
Research Institution: ScitoVation

Project Title: Development of a fit-for-purpose in vitro model of lung toxicity
Principal Investigator: Scaglione, Jamie
Research Institution: ScitoVation

Project Title: Application of Toxicogenomics in Next-Generation Risk Assessment
Principal Investigator: Nong, Andy
Research Institution: ScitoVation

Address Topical Challenges Faced by the Chemical Industry: Novel Techniques and Tools

Project Title: Developing In Vitro Metabolic Clearance Data to Support Development of the Internal Threshold of Toxicological Concern (iTTC)
Principal Investigator: Black, Sherry
Research Institution: RTI

Project Title: Survey and Development of a Peer Review Process for Exposure Models
Principal Investigator: Hays, Sean
Research Institution: SciPinion

Project Title: Evaluation of USEPA’s Generalized Read-Across (GenRA) Version 3 Using Example Case Studies
Principal Investigator: Borghoff, Susan
Research Institution: ToxStrategies