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ACC’S High Phthalates Panel Comments on Welch et Al. 2022

Study Confirms All Phthalates Are Not the Same, No Association Found Between DINP, DIDP and Increased Preterm Births

Allison Edwards

WASHINGTON (July 18, 2022) — The American Chemistry Council’s (ACC) High Phthalates Panel released the following statement in response to the recent publication of Welch et al. 2022, Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth:

“As confirmed by this research, the high molecular weight phthalates, DINP and DIDP, are not associated with statistically significant increased odds of preterm birth. This distinction is important for those interpreting the results to recognize, as this confirms the differences between phthalate compounds and adds to the growing body of scientific support for DINP and DIDP. 

“In the past six years, numerous government regulatory agencies, including the European Chemicals Agency (ECHA), the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS), and Canada’s Ministry of Environment and Climate Change and Ministry of Health, have found, after rigorous regulatory review, that DINP and DIDP are safe as currently used.”

“We support the use of robust, and reproducible science in protecting public health. While we are pleased that this study provides more evidence of the clear biological distinctions between different compounds in the broad family of phthalates, as the authors note, there are significant methodological shortcomings with this research. Welch et al. 2022 fails to account for well-established risk factors for preterm birth, including unhealthy diet, gestational diabetes and hyperglycemia, and Urinary Tract Infections (UTI), some with stronger associations from larger sample sizes. The lack of such methodological rigor makes the results of this study questionable, especially in light of the “seemingly small in magnitude”1 odds ratios in question.”

1 Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth

American Chemistry Council

The American Chemistry Council’s mission is to advocate for the people, policy, and products of chemistry that make the United States the global leader in innovation and manufacturing. To achieve this, we: Champion science-based policy solutions across all levels of government; Drive continuous performance improvement to protect employees and communities through Responsible Care®; Foster the development of sustainability practices throughout ACC member companies; and Communicate authentically with communities about challenges and solutions for a safer, healthier and more sustainable way of life. Our vision is a world made better by chemistry, where people live happier, healthier, and more prosperous lives, safely and sustainably—for generations to come.

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