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Science & Research

The ACC Olefins Panel has a long history of conducting scientific research and communicating critical information to stakeholders, including regulatory agencies in the U.S and abroad, in order to better understand the hazards and risks potentially associated with exposures to Olefins. This includes studies related to understanding the hazard potential and /or exposure scenarios for 1, 3-butadiene and ethylene.

Reports and Studies

Dose-Dependence Of Chemical Carcinogenicity: Biological Mechanisms For Thresholds And Implications For Risk Assessment

The review highlights some of the key discoveries and technological advances that have influenced scientific understanding of chemical carcinogenesis over the last fifty years and provides case studies to demonstrate the utility of these modern technologies in providing a biologically robust evaluation of chemical dose-response for cancer risk assessment.

COTOX_2018_22_R1 (doi: TBD)

Transforming Regulatory Safety Evaluations Using New Approach Methodologies: A Perspective of an Industrial Toxicologist 

Reports and Studies

Predictive Analytics Toolkit (PAT)

The replacement of traditional toxicity testing with prediction modeling for determining hazards and risks is rapidly advancing.