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Transcriptomic re-analyses of human hepatocyte spheroids treated with PFAS reveals chain length and dose-dependent modes of action

Keywords: Transcriptomics, PFAS, Lipid Metabolism, Toxicogenomics, Risk Assessment, Mode-Of-action

Authors: Rasim Barutcu A, Black M, Andersen M

To identify pathway perturbations and examine biological modes of action (MOAs) for various perfluoroalkyl substances, we re-analyzed published in vitro gene expression studies from human primary liver spheroids. 
 

Fluorotechnology / Per- and Polyfluoroalkyl Substances (PFAS)
Abstract
Foundation for Chemistry Research & Initiatives

The Foundation for Chemistry Research and Initiatives (Foundation), is a 501(c)(3) tax-exempt organization established by the American Chemistry Council (ACC). Through partnerships with academia, research institutions, governmental and non-governmental organizations, and private corporations, the Foundation supports scientific research on various chemistries; the development of training programs for the safe use and application of products; and programs demonstrating chemistry’s contribution and benefits to society.

The Foundation was established in 1995 as the Research Foundation for Health and Environmental Effects (RFHEE).