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Estimating Provisional Margins of Exposure for Data-Poor Chemicals Using High-Throughput Computational Methods

Collaborating Organization(s): U.S. EPA Office of Chemical Safety and Pollution Prevention, ScitoVation, U.S. National Toxicology Program, 21st Century Tox Consulting LLC, U.S. EPA National Center for Computational Toxicology

Keywords: TTC, computational toxicology, in silico, high-throughput risk prioritization, margin of exposure (MoE)

Authors: Nicolas CI, Linakis MW, Minto MS, Mansouri K, Clewell RA, Yoon M, Wambaugh JF, Patlewicz G, McMullen PD, Andersen ME, Clewell HJ

Exposure Science
Abstract
American Chemistry Council

The American Chemistry Council’s mission is to advocate for the people, policy, and products of chemistry that make the United States the global leader in innovation and manufacturing. To achieve this, we: Champion science-based policy solutions across all levels of government; Drive continuous performance improvement to protect employees and communities through Responsible Care®; Foster the development of sustainability practices throughout ACC member companies; and Communicate authentically with communities about challenges and solutions for a safer, healthier and more sustainable way of life. Our vision is a world made better by chemistry, where people live happier, healthier, and more prosperous lives, safely and sustainably—for generations to come.