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Dosimetry of N 6-Formyllysine Adducts Following [13C2H2]-Formaldehyde Exposures in Rats.

Authors: Edrissi, Bahar, Koli Taghizadeh, Benjamin C. Moeller, Dean Kracko, Melanie Doyle-Eisele, James A. Swenberg, and Peter C. Dedon.

The research found that Exogenous N6-formyllysine was detected in the nasal epithelium, but was not detected in the lung, liver, or bone marrow. Endogenous adducts dominated at all exposure conditions, The results parallel previous studies of formaldehyde-induced DNA adducts.