The peer-reviewed published studies on the mode of action, toxicology, and epidemiology of formaldehyde below demonstrate:
- Inhaled formaldehyde does not migrate beyond the nose, the portal of entry, and exogenous formaldehyde is not found in distant sites in the body.
- There is a threshold-like dose response for nasal tumor formation in rats and updated mode of action data. Epidemiological studies report no increased cancer risk at high concentrations.
- A causal association between inhaled formaldehyde and lymphohematopoietic cancers, including myeloid leukemia, is not biologically plausible.